Creating the Bubble Up Biscuit Pizza Casserole is straightforward. Follow these simple steps:

1. Preheat Oven: Preheat your oven to 350°F (175°C). Spray a 9×13 inch baking dish with cooking spray.
2. Prepare Biscuits: Open the cans of biscuit dough and cut each biscuit into quarters.
3. Combine Ingredients: In a large bowl, mix the biscuit pieces, pizza sauce, mozzarella cheese, pepperoni, and any additional toppings. Stir until everything is evenly coated.
4. Transfer to Dish: Pour the mixture into the prepared baking dish, spreading it out evenly.
5. Season: Sprinkle Italian seasoning and garlic powder over the top.
6. Bake: Place in the preheated oven and bake for 25-30 minutes, or until the biscuits are golden brown and cooked through.
7. Cool Slightly: Remove from the oven and let it cool for about 5 minutes before serving.

This simple method ensures that your casserole is delicious every time!